Fig. 2: Microglia Iba1+ in the substantia nigra. | npj Parkinson's Disease

Fig. 2: Microglia Iba1+ in the substantia nigra.

From: Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein pre-formed fibrils Parkinson’s disease mouse model

Fig. 2

A Representative photos of the four Iba1+ morphological phenotypes quantified. Scalebar = 10 µm. B Representative image of Iba1 staining in Substantia nigra (SN, both compacta and reticulata). Scalebar = 100 µm for all low-magnification images, and 50 µm for inserts. Stereological quantification of total Iba1 cells in the SN at 1 month (C) and 6 months post-injection (E). Three-way ANOVA with matched values followed by an uncorrected Fisher’s LSD with Bonferroni correction applied. Corrected values are displayed on the graphs (*<p = 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001). The distribution of the morphological profiles is displayed as the average percentage of total Iba1+ at 1 month (D) and 6 months post-injection (F). Two-way ANOVA (matched values when sides are in the same group, or not matched values same sides and treatment) followed by Sidak’s multiple comparisons. * vs. the contralateral side within the same group and subtype. # vs. to the same side and treatment across genotypes. P #/* < 0.05, ##/**≤0.01, ###/ *** ≤ 0.001, ####/****≤0.0001. (see further stats in Supplementary Table 3) Data are average ±SD, n = 4–10.

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