Fig. 6: Analysis of pathology. | npj Parkinson's Disease

Fig. 6: Analysis of pathology.

From: Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein pre-formed fibrils Parkinson’s disease mouse model

Fig. 6

A Representative photos of MJF14, p62, and pSer129 staining in the amygdala and substantia nigra 6 months post-injections. Scalebar = 50 µm for all low magnification in the same area and marker, and 25 µm for all inserts. Graphs show the percentage of area covered by MJF14 staining in the ipsilateral side at 1 and 6 months post-injection in the amygdala (B) and SN (C). D, E Graphs show the percentage of area covered by positive p62 staining at 1-month and 6-month post-injection in the amygdala (D) and the substantia nigra (SN). Graphs show the percentage of area covered by pser129 staining in PBS, MONO, and PFF-injected animals 6 months post-injected in the amygdala (F) and SN (G). Two-way ANOVA followed by Sidak’s multiple comparisons (See further stats in Supplementary Table 3).). *<p = 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. All data are presented as mean ± SD. n = 6–10.

Back to article page