Fig. 8: Assessment of tyrosine hydroxylase-expressing neurons in the substantia nigra. | npj Parkinson's Disease

Fig. 8: Assessment of tyrosine hydroxylase-expressing neurons in the substantia nigra.

From: Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein pre-formed fibrils Parkinson’s disease mouse model

Fig. 8

Lack of functional STINGgt/gt does not influence long-term degeneration of dopaminergic neurons. A Representative image of tyrosine hydroxylase (TH) immunostaining in the SN at 1- and 6 months post-injection. Scalebar = 200 µm for low-magnification images and 50 µm for inserts. Unbiased stereological quantification of the number of TH+ neurons in the ipsilateral SN as the percentage of contralateral at 1 month (n = 4–10) (B) and 6 months (n = 4–10) (C) post-injection. Two-way ANOVA followed by Sidak’s multiple comparisons (See further stats in Supplementary Table 3). Data are mean +SD. *<p = 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. SN=Substantia nigra.

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