Table 3 Comparison of serum bile acid levels between PD-NC and PD-CI groups

From: Classifying the risk of cognitive impairment in Parkinson’s disease using serum bile acid profiles and machine learning

Variables

PD-NC

PD-CI

P

FDR

Fold Change

CA

285.210 (973.69)

198.101 (496.74)

0.008

0.041

0.69

CDCA

765.563 (1217.65)

503.140 (1485.76)

0.069

0.147

0.66

DCA

179.591 (385.58)

276.913 (666.88)

0.000

0.001

1.54

LCA

18.969 (23.62)

20.731 (17.40)

0.198

0.370

1.09

GCA

238.700 (502.22)

275.969 (768.21)

0.605

0.649

1.16

GCDCA

1415.398 (1386.30)

1412.696 (1934.85)

0.536

0.649

1.00

GDCA

208.500 (497.27)

224.772 (422.08)

0.592

0.649

1.08

GLCA

10.750 (25.32)

6.917 (18.94)

0.024

0.031

0.64

TCA

51.614 (181.48)

25.410 (163.09)

0.045

0.050

0.49

TCDCA

154.150 (248.50)

160.931 (459.73)

0.475

0.649

1.04

TDCA

32.771 (89.57)

42.826 (96.10)

0.895

0.897

1.31

TLCA

1.785 (3.15)

2.191 (5.99)

0.334

0.554

1.23

UDCA

205.981 (258.88)

98.016 (283.85)

0.002

0.016

0.48

GUDCA

187.823 (259.09)

170.192 (407.09)

0.545

0.649

0.91

TUDCA

8.005 (22.47)

12.095 (43.46)

0.018

0.050

1.51

  1. Data are presented as median (interquartile range); P-values were calculated by the Mann–Whitney U test, with significant values (P < 0.05) shown in bold. FDR, false discovery rate, was computed using the Benjamini–Hochberg correction for multiple testing. Fold Change (FC) was calculated as the ratio of group medians (PD-NC/PD-CI), representing the relative change in bile acid concentration between Parkinson’s disease patients and healthy controls.
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