Fig. 8: Effects of TLR4 inhibitor on intestinal microbial community composition and function in LRRK2R1627P rats. | npj Parkinson's Disease

Fig. 8: Effects of TLR4 inhibitor on intestinal microbial community composition and function in LRRK2R1627P rats.

From: LRRK2R1627P mutation amplifies environmental risk factors induced chronic inflammation and α-synuclein aggregation in the gut of rats

Fig. 8: Effects of TLR4 inhibitor on intestinal microbial community composition and function in LRRK2R1627P rats.The alternative text for this image may have been generated using AI.

a Alpha-diversity was determined using Shannon index, Ace index, Chao index, Sobs index, and Simpson index based on OTU level. b Comparison of the microbial dysbiosis index in ConWT, ConRP and TAKRP group. c Bar plot of the top 20 most abundant species at genus level. d Heatmap to visualize the top 20 most abundant species at genus level. e LEfSe analysis of characteristic microbial composition in three groups. LDA score threshold > 2.0. f Species difference test of top 5 most abundant species at genus level. g Gut microbiota phenotypes based on BugBase predictive analysis, including Gram negative, Gram positive, aerobic, anaerobic, facultatively anaerobic. Non-parametric test was used. h Species composition of Gram negative phenotypes. i, j KEGG level1 and level2 annotations by PICRUSt2-predicted based on 16S rRNA gene sequencing data of the three groups. n = 6 in ConWT, n = 8 in ConRP, n = 7 in TAKRP. *p < 0.05, **p < 0.01.

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