Fig. 9: Dynamic changes of small intestinal homeostasis in LRRK2R1627P rats from young to old. | npj Parkinson's Disease

Fig. 9: Dynamic changes of small intestinal homeostasis in LRRK2R1627P rats from young to old.

From: LRRK2R1627P mutation amplifies environmental risk factors induced chronic inflammation and α-synuclein aggregation in the gut of rats

Fig. 9: Dynamic changes of small intestinal homeostasis in LRRK2R1627P rats from young to old.

LRRK2R1627P mutation significantly reduced intestianl endogenous total LRRK2, pT73-Rab10 protein level and the number of Paneth cells. Compared with age-macthed WT rats, LRRK2R1627P rats showed shorter small intestine length, villus height, and crypt depth (from 8 months old); a significant decrease in the number of goblet cells, expression of barrier proteins, and microbial community diversity (from 16 months old); and a marked increase in the TLR4/MyD88/NF-κB signaling pathway, the number of M1 macrophages, the expression of pS129-α-Syn, and the abundance of Lactobacillus (from 16 months old). Long-term administration of the TLR4 inhibitor TAK-242 effectively ameliorated the imbalance in intestinal homeostasis of LRRK2R1627P rats.

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