Fig. 2: Shared and specific alterations in putaminal amino acid concentrations of untreated and L-DOPA-treated MPTP-intoxicated monkeys relative to controls. | npj Parkinson's Disease

Fig. 2: Shared and specific alterations in putaminal amino acid concentrations of untreated and L-DOPA-treated MPTP-intoxicated monkeys relative to controls.

From: Ultra-performance liquid chromatography–mass spectrometry analysis of post-mortem brain tissue reveals specific amino acid profile dysregulation in Parkinson’s disease and Alzheimer’s disease patients

Fig. 2: Shared and specific alterations in putaminal amino acid concentrations of untreated and L-DOPA-treated MPTP-intoxicated monkeys relative to controls.The alternative text for this image may have been generated using AI.

The Venn diagram illustrates the overlap between amino acids significantly upregulated in untreated MPTP-intoxicated monkeys compared with controls (green) and those upregulated in MPTP + L-DOPA-treated monkeys compared with controls (purple). Five amino acids — serine, GABA, phenylalanine, valine, and isoleucine — were commonly upregulated in both untreated and L-DOPA-treated MPTP-intoxicated monkeys relative to controls. Leucine, aspartate, and glutamate were selectively increased in MPTP-intoxicated monkeys, whereas glycine, citrulline, and threonine were selectively increased in the MPTP + L-DOPA–treated group. Ctrl control, MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

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