Fig. 2
From: Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
The cell of origin of cholangiocarcinoma. Schematic micrograph of lineage tracing experiments in mouse demonstrating the contribution of cytokeratin-19-positive ductular cells and albumin or transthyretin-positive hepatocytes to the formation of tumours exhibiting biliary differentiation. Cholangiocarcinoma can arise from either cholangiocytes, immature ductules or through transdifferentiation of hepatocytes
