Fig. 3

Morphological and functional analysis of the hearts one month after MI. a Representative images of the hearts of selected CC RI strains one month after MI, aligned from the most pronounced (top, in red) to the least pronounced (bottom, in green) LVSD/HF phenotype. b Changes in EF for individual strains (green bars—before, red bars—1 m after MI). Strains are aligned according to the degree of EF reduction after MI (ΔEF—blue dots). c LV volume changes (green bars—before, red bars—1 m after MI). Strains are aligned according to the degree of LV dilation after MI (LVD—blue dots). Green and red arrows on X axis indicate the strains with correlating ΔEF and LVD values (LVSD/HF phenotype). Error bars on the graphs denote standard deviation. Data are presented as mean value ± SD of minimum three biological replicates. (Exact number biological replicates per strain is provided in Supplementary Tables S1 and S2.) d TOFU_FB strain as a potential model of MI-induced dilated cardiomyopathy. Representative echographic images of the LV in longitudinal axis before (top) and after MI (middle), whole-mount image of the same heart one month after MI (bottom). e NUK_AC strain as a potential model of spontaneous right ventricular hypertrophy. Normal heart (left), heart with severe RV hypertrophy (right). Scale bars, 5 mm (a, d)