Fig. 6
From: Variable outcomes of human heart attack recapitulated in genetically diverse mice
Expression profiling and functional annotation clustering. a A heatmap of a selected gene expression cluster correlating with MI-induced left ventricular systolic dysfunction (LVSD) and heart failure (HF) phenotype. The FIM, POH, and PEF strains displayed minimal LVSD, whereas the B6, DAVIS, and BOON strains displayed severe LVSD after MI (see Fig. 3A). b Expression profile of genes involved in oxidative phosphorylation overrepresented in cluster a (p-value > 2.00E − 04). c–e Representative correlation plots of top correlates of gene expression vs. LVSD/HF-related traits (LVD and ΔEF). c Positive correlation of Usmg5 mRNA expression levels with the LVD phenotype (correlation coefficient − 0.92, p-value = 1.88E − 06). d Negative correlation of Nab1 mRNA expression levels with the ΔEF phenotype (correlation coefficient − 0.90, p-value = 9.50E − 06). e Positive correlation of Atp5k mRNA expression levels with the LVD phenotype (correlation coefficient − 0.87, p-value = 7.91E − 05)
