Fig. 2: Tissue-engineered skin substitutes (TESSs) fabricated with human adult skin cells and their role in wound healing process. | npj Regenerative Medicine

Fig. 2: Tissue-engineered skin substitutes (TESSs) fabricated with human adult skin cells and their role in wound healing process.

From: Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries

Fig. 2

After a deep, severe or chronic injury where, normal phases of healing are not possible, fabrication of TESSs from cells of a human skin biopsy is the most usual advanced therapy. Keratinocytes, fibroblasts and the rest of epithelial cells are isolated, expanded and used in combination with a biological matrix to produce sheets of cultured epithelial substitutes (CESs), cultured dermal substitutes (CDSs) and composite skin substitutes (CSSs), which are engrafted to promote and facilitate cell activation and the release of growth factors necessary to achieve reparation, regeneration and homeostasis of skin. Created with BioRender.com.

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