Fig. 2: TVC design and creation.
From: A therapeutic vascular conduit to support in vivo cell-secreted therapy
a Schematic representation of the TVC design with an acellular vessel and hydrogel coating. Inset illustrates that cultured, genetically modified FBs are incorporated into the coating. b Light microscopic gross/macroscopic view of an acellular vessel with a fibrin hydrogel coating. Hydrogel shown is cell free to illuminate the difference between the vessel and hydrogel coating. c Biomechanical property of suture retention strength was measured for dUA and coated dUA. Fibrin alone tested below the limits of assay (5 g). No statistically significant difference was observed between dUA and coated dUA (p = 0.2193). Means with standard deviations shown, n = 3 for each group. d Longitudinal and circular cross-sections of the TVC stained using H&E.
