Fig. 4: TVCs implanted into nude rats.
From: A therapeutic vascular conduit to support in vivo cell-secreted therapy
a TVC implanted into rat as an end-to-end abdominal aorta graft and demonstrates integration and microvascularization when explanting at 3 months. b EPO secreting TVCs increase blood plasma EPO levels compared to empty vector TVCs and subcutaneous implants of EPO-FBs. c Hemoglobin (Hgb) levels were elevated for up to 1 month after implanting EPO-TVCs. From statistical analyses, EPO levels for empty vector control-TVC vs EPO-TVC p < 0.0001, EPO-TVC vs subcutaneous p < 0.0001, and empty vector control-TVC vs subcutaneous was not statistically different. Hgb levels control vs EPO p < 0.001, EPO vs subcutaneous p = 0.0384, and control vs subcutaneous p = 0.0493.
