Fig. 5: Regeneration of irradiation damaged salivary gland by transplanting MSCs to irradiated mice. | npj Regenerative Medicine

Fig. 5: Regeneration of irradiation damaged salivary gland by transplanting MSCs to irradiated mice.

From: Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration

Fig. 5

a Flow diagram showing the schematic for the experimental plan. b H&E staining showing glandular morphology of salivary gland in control (mock radiated), irradiated and irradiated + transplanted MSCs. Images were taken using ×20 objective and scale bar = 100 μm. A, indicates acinar and D indicates ductal cells. c Confocal images showing the presence of stem cell marker (CD44, shown by arrow) in the salivary gland of mice from radiated and MSCs transplanted mice growing in 0.5 mM Ca2+ or 2 mM Ca2+ after radiation treatment. d The bar graph represents saliva secretion in control, irradiated and MSCs transplanted mice post radiation. The data presented are from 8 to 10 mice in each group expressed as mean ± standard error. *p ≤ 0.001 (Student’s t-test).

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