Fig. 4: Comparison of SOX9 expression in fractured bones and amputated limbs.
From: The specialist in regeneration—the Axolotl—a suitable model to study bone healing?
a In axolotl amputated limbs, SOX9-positive cells are present in 3 weeks blastema and cartilaginous condensations in 3 months regenerate. b, c In axolotl fixated and non-stabilized fractures, SOX9 expression is observed in pre-cartilage cells at 3 weeks post-fracture and in callus cells at 3 months post-fracture. d In murine fractures, SOX9-positive cells are present at 1 week post-fracture, and at 2 weeks, bone bridging by woven bone is in progress. Scale bars 200 µm. Yellow dashed line - bone, red dashed line - callus, BM – bone marrow, M – muscle, C – cartilage, Ca – callus, BL – blastema, B – bone.
