Fig. 1: Rrm2b was upregulated at late stage of regeneration in wild-type skeletal muscle.
From: Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
a After induction of MuSC differentiation in vitro, the Rrm2b mRNA levels were significantly upregulated at days 3, 5, and 7. b Rrm2b expression levels in the skeletal muscle (gastrocnemius) of 5-month-old F/F mice at days 1, 4, 7, and 14 after damage. The values at day 0 served as the nondamaged controls, and 3–5 mice were in each group. c Rrm2b IHC expression in skeletal muscle (femoris) was higher in the damaged region 14 days after BaCl2 injection. ND, nondamaged region. D, damaged region showing centrally nucleated fibers. Scale bar, 100 µm. The mice were 3 months old. The results are presented as the mean ± SD. Statistical analysis of differences between the groups was performed by two-tailed, unpaired t-tests, and the P-values were calculated. Asterisks denote statistically significant changes from the control and are defined as *P < 0.05; **P < 0.01.
