Fig. 3: Grafted cerebral organoids extend long-distance projections to specific brain areas in stroke mice 180 days after transplantation. | npj Regenerative Medicine

Fig. 3: Grafted cerebral organoids extend long-distance projections to specific brain areas in stroke mice 180 days after transplantation.

From: Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke

Fig. 3: Grafted cerebral organoids extend long-distance projections to specific brain areas in stroke mice 180 days after transplantation.

a Schematic showing the GFP+ grafts in the infarct core and peri-infarct area on the coronal sections of brain (middle), and images showing graft-derived projections in the contralateral and ipsilateral corpus callosum (CC), hippocampus (Hip) (upper) and striatum (Str), ipsilateral S2 and internal capsule (IP). Scale bar, 50 μm. b Schematic showing the GFP+ grafts in the infarct core and peri-infarct area on the sagittal sections of brain (middle), and images showing graft-derived projections in the CC, and striatum, IC, cerebral peduncle (CP), ventral posterior thalamic nucleus (VP), spinal trigeminal nucleus (Sp5) and brainstem. Scale bar, 20 μm.

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