Fig. 2: Genetic signature studies reveal similarities in porcine and human biliary tree stem cells.

a Correlation analyses of hBTSCs, hHpSCs, hHBs and hAHeps presented as four distinct populations. b Expression and clustering analysis for the top 3000 genes of hBTSCs, hHpSCs, hHBs, and hAHeps. c Volcano Plots demonstrate the similarities and differences in gene expression between the cell types. The red spots indicate genes that are upregulated in the cell type, while the blue spots indicate the ones that are downregulated. The spots locate in further distance to the center of the graph are the genes that have the most distinct expression in one of the cell types. The adjusted p values are all < 0.05. Only the genes that had fold changes >2 (log₂ fold change (log₂FC) > 1) were colored in red or blue in the volcano plots. d The clustering analysis of the correlation heatmaps of all genes was the most distinct among all the five cell subpopulations. e The top 5000 genes that had the most significant standard deviation (SD) values were presented to show the similarities among pBTSCs and hBTSCs, hHpSCs versus hHBs and hAHeps.