Fig. 7: ScRNA-seq analysis of epidermal–dermal cell communication in restored adult cell cultures after environmental reprogramming. | npj Regenerative Medicine

Fig. 7: ScRNA-seq analysis of epidermal–dermal cell communication in restored adult cell cultures after environmental reprogramming.

From: Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures

Fig. 7: ScRNA-seq analysis of epidermal–dermal cell communication in restored adult cell cultures after environmental reprogramming.

a ScRNA-seq analysis shows an increased number of basal cells (Col17a1+), DP cells (Lef1+, Bmp7+), and a decreased number of suprabasal cells (Klk7+) in restored adult cells. b ECM mode of CellChat analysis shows increased EMI in restored adult cells. False discovery rate <0.05 and Log2 fold change >1. c Secreted mode of CellChat analysis shows enhanced Tgfb and Fgf signaling network between epidermal and dermal cells in the restored group. d Summary diagram shows the mechanism of CMU formation.

Back to article page