Fig. 2: The hASCs expressed higher levels of tenogenic genes on substrates coated with collagen I and fibromodulin. | npj Regenerative Medicine

Fig. 2: The hASCs expressed higher levels of tenogenic genes on substrates coated with collagen I and fibromodulin.

From: Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration

Fig. 2: The hASCs expressed higher levels of tenogenic genes on substrates coated with collagen I and fibromodulin.

a Screening of teno-inductive ECM components via gene expression of tenogenic markers of SCX, TNMD, COL1 and DCN. *p < 0.05 comparing to control. b hASCs expressed higher levels of tenogenic genes on smooth polydimethylsiloxane membranes coated with both collagen I and fibromodulin using fibronectin coating as a control. c Fibromodulin coated microgroove substrate promoted tenogenic differentiation of hASCs synergistically. Significant differences existed between two groups labeled with different letters. SCX scleraxis, TNMD tenomodulin, Col1 collagen I, DNC decorin, S smooth surface, G microgroove surface. All error bars indicate standard deviation.

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