Fig. 8: BMP2 promotes wound healing via inducing nerves regeneration in vivo. | npj Regenerative Medicine

Fig. 8: BMP2 promotes wound healing via inducing nerves regeneration in vivo.

From: Peripheral nerve-derived CSF1 induces BMP2 expression in macrophages to promote nerve regeneration and wound healing

Fig. 8: BMP2 promotes wound healing via inducing nerves regeneration in vivo.

A Experimental schematic of macrophage depletion wound wound healing with BMP2 treatment. B Photographs of Control, PBS-Lipo, Clo-Lipo, and Clo-Lipo+BMP2 wounds at different time points. C Superimposed wounds images of Control, PBS-Lipo, Clo-Lipo, and Clo-Lipo+BMP2 wounds at different time points. D Quantitative analysis of the relative wound areas at different times. E IF of β3-tubulin and NF in nerves of different treatments. Scale bar, 200 μm. F Quantitative analysis of the area of β3-tubulin on days 14. G Quantitative analysis of the area of NF on days 14. H Schematic representation of the mechanism by which M2 macrophages-derived CSF1 regulates peripheral nerves regeneration. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Data are shown as mean ± s.e.m.

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