Fig. 6: HA-Col click gels increased corneal re-epithelialization rate compared to other gels and mitigated corneal opacity in rabbits. | npj Regenerative Medicine

Fig. 6: HA-Col click gels increased corneal re-epithelialization rate compared to other gels and mitigated corneal opacity in rabbits.

From: Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels

Fig. 6: HA-Col click gels increased corneal re-epithelialization rate compared to other gels and mitigated corneal opacity in rabbits.

a Representative fluorescein staining photos of rabbit corneas from different treatment groups. b HA-Col click gel treated corneas showed a higher probability of complete re-epithelialization over time compared to other groups, although there were no significant differences among the treatments. n = 6 (PBS), 5 (HA-Col and Col groups), or 3 (HA-Col UV group). c Representative photos of rabbit corneas from different treatment groups. d Quantification of normalized central corneal opacity (gray value normalized to the peripheral cornea) in rabbit corneas with all treatment groups. Data present mean ± SEM. n = 3 (Col and HA-Col UV groups), 4 (PBS group), or 5 (HA-Col group). A two-way ANOVA analysis was used to calculate the p values. *p < 0.05, **p < 0.01. HA is hyaluronic acid. Col is collagen. PBS is phosphate buffer solution. Graphs were created in GraphPad Prism 10.

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