Fig. 5: ARPBP promotes regenerative wound healing in rats.
From: Systemic factors associated with antler growth promote complete wound healing
a, b Neogenic HFs and SGs in the ARPBP-treated wounds, stained with CK19 (green), CK14 (red), Lef1 (green and brown), and oil red O (red). The white arrowheads point to the neogenic HFs and SGs. c, d Quantification of neogenic HFs and SGs. Note that the numbers of regenerated HFs and SGs in the ARPBP treatment group were significantly higher than those in the non-ARPBP treatment group. Data are shown as the mean ± SEMs (n = 3) with ten fields randomly chosen from three replicates of each tissue section for statistical analysis. e Diving cells in the wound bed stained with Ki67 (green) and CK19 (red). Note that ARPBP treatment group had significantly more stained cells (white arrowheads) than the non-ARPBP group. f, g Quantification of diving cells in epidermis and dermis. Note that the ARPBP group had significantly more ki67+ cells in both epidermis and dermis than the non-ARPBP group. Data are shown as the mean ± SEMs (n = 3) with six fields randomly chosen from three replicates of each tissue section for statistical analysis. h ECM ultrastructural properties for healed skin on POD 28. Note that the ECM architecture in the ARPBP group was comparable to normal skin, whereas fibrosis characteristics were evident in the non-ARPBP group.
