Fig. 4: In vivo safety and tumorigenicity studies of RPE cells in the RNU rat model. | npj Regenerative Medicine

Fig. 4: In vivo safety and tumorigenicity studies of RPE cells in the RNU rat model.

From: Allogeneic RPE cell suspension manufactured at scale demonstrating preclinical safety and efficacy led to IND approval

Fig. 4

A Representative images of H&E staining of retinal cross-sections from RNU rats injected with iPSC to demonstrate tumor formation in 2 months (positive control). Formation of cell/tissue types representing ectoderm, endoderm, and mesoderm are evident. B Images of fundus, H&E staining, and corresponding HNM/DAPI staining of retinal cross-sections from RNU rats injected with Eyecyte-RPE generated using the different protocols (4 and 9 months post transplantation). Cells survived upto 9 months without any growth or tumor formation. Scale bars indicate 1000 μm and 100 μm respectively.

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