Fig. 6: Translational roadmap and mechanistic model of CCNA2 gene therapy for cardiac regeneration.
From: Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice
Building upon our previous in vivo studies in rodent and porcine myocardial infarction models, which demonstrated functional recovery via CCNA2 gene therapy (1-3)13,19,20,21,22, this study provides direct evidence of complete cytokinesis in cultured human adult cardiomyocytes. Complementary transcriptomic analyses from fetal and adult human hearts, as well as CCNA2 transgenic models, reveal reactivation of reprogramming, fetal-like, and proliferative gene programs. The schematic illustrates the translational trajectory from preclinical to mechanistic insights and highlights CCNA2 as a driver of cardiomyocyte cell cycle reentry, cytokinesis, and regenerative gene expression. The illustration was created using BioRender (https://biorender.com).
