Table 5 Studies examining magnetic resonance spectroscopy (MRS)
Author | Year | n (HC/SZ/ SAD/ BD) | Bipolar subtype | Illness duration | Medication status | Area of interest | MRS | Sequence | Tesla | Main findings |
|---|---|---|---|---|---|---|---|---|---|---|
Molina et al. 95 | 2007 | 10/11/0/13 | P/NP | Chronic | Medicated | DLPFC | SV | PRESS | 1.5 | NAA/Cr decreased in SZ and BD No abnormalities in Cho/Cr in either group compared to HC |
Crespo et al. 97 | 2008 | 15/14/0/17 | NP | Chronic | Medicated | dACC | SV | PRESS | 1.5 | NAA/Cho SZ < HC and BD; Cho/Cr SZ > HC and BD; NAA/Cr no group differences |
Ongur et al. 98 | 2009 | 22/8/7/15 | P | Chronic | Medicated | ACC/POC | SV | PRESS | 4 | Cr HC = BD > SZ in both voxels |
Ongur et al. 143 | 2010 | 20/15/0/15 | P | Chronic | Medicated | ACC/ POC | SV | PRESS | 4 | Numerically shortened T2 relaxation times in BD and SZ |
Kalayci et al. 96 | 2012 | 15/15/15/15 | Chronic | Medicated | DLPFC | SV | PRESS | 1.5 | NAA HC > BD, SZ, SAD; Cho HC > BD, SAD; Cr C > BD, SAD, SZ | |
Atagun et al. 99 | 2015 | 30/30/0/28 | Chronic | Medicated | Heschl’s gyrus | SV | PRESS | 3 | Glu, NAA, and Cr HC > BD in left hemisphere; no group differences in right hemisphere | |
Atagun et al. 100 | 2016 | 30/25/0/48 | Chronic | Medicated | Perisylvian structures | SV | MEGA-PRESS | 3 | GABA SZ > BD = HC |
