Table 1 Previously reported candidate gene studies showing significant association with SZ cohorts from Indian population
From: Attempts to replicate genetic associations with schizophrenia in a cohort from north India
(A) Markers associated with schizophrenia | ||||
|---|---|---|---|---|
Gene | Marker | p-value | # of cases/controls | Reference |
IL1A | rs1800587 | 0.03 | 488/186 | Srinivas et al.66 |
IL16 | rs1800795 | 0.04 | 492/488 | |
TNFA | rs361525 | 0.02 | 494/486 | |
PPP3CC | rs7430 | 0.001 | 1017/1073 | John et al.40 |
XRCC1 | rs25487 | 0.003 | 260/263 | Sujitha et al.67 |
GRM7 | rs3864075 | 0.004 | 840/876 | Jajodia et al.37 |
NRG1 | rs17603876 | 0.8 × 10− 4 | 840/876 | |
STT3A | rs548181 | 0.1 × 10−4 | 840/876 | |
DNMT1 | rs2114724 | 0.02 | 330/302 | Saradalekshmi et al.68 |
DNMT1 | rs2228611 | 0.002 | 330/302 | |
SLC6A3 | rs403636 | 0.06 | 1007/1019 | Kukshal et al.69 |
DBH | rs6271 | 0.004 | 1007/1019 | |
SLC18A2 | rs363399 | 0.05 | 1007/1019 | |
SLC18A2 | rs363338 | 0.07 | 1007/1019 | |
SLC18A2 | rs10082463 | 0.07 | 1007/1019 | |
SLC18A2 | rs363285 | 0.09 | 1007/1019 | |
COMT | rs933271 | 0.06 | 1007/1019 | |
COMT | rs4680 | 0.05 | 1007/1019 | |
COMT | rs9332377 | 0.02 | 1007/1019 | |
NRG1 | rs35753505 | 0.04 | 1007/1009 | Kukshal et al.38 |
NRG1 | rs4733263 | 0.04 | 1007/1009 | |
NRG1 | rs6994992 | 0.03 | 1007/1009 | |
NRG1 | 420M9-1355 | 0.02 | 1007/1009 | |
NRG1 | rs1354336 | 0.01 | 1007/1009 | |
NRG1 | rs10093107 | 0.008 | 1007/1009 | |
NRG1 | rs3924999 | 0.02 | 1007/1009 | |
NRG1 | rs11780123 | 0.01 | 1007/1009 | |
COMT | rs362204 | 0.028 | 215/215 | Srivastava et al.70 |
COMT | rs4680 | 0.029 | 254/225 | Gupta et al.71 |
SLC6A4 | 5HTTLPR | 0.08 | 243/243 | Vijayan et al.72 |
SLC6A4 | rs20066713 | 0.001 | 243/243 | |
SLC6A4 | STin2 | 0.001 | 243/243 | |
DRD3 | rs10934254 | 0.03 | 141 trios | Talkowski et al.73 |
SYNGR1 | rs909685 | 0.01 | 193/107 | Verma et al.36 |
SYNGR1 | rs715505 | 0.00007 | 193/107 | |
SYNGR1 | rs6001566 | 0.03 | 193/107 | |
NOTCH4 | 197/198(GAAG)50 | 0.06 | 182 trios | Prasad et al.74 |
NOTCH4 | (CTG)6 | 0.02 | 182 trios | |
Ch 22 CAG repeat | 22CH3 | < 0.02 | 108/129 | Saleem et al.75 |
(B) Markers associated with tardive dyskinesia and cognitive domains | ||||||
|---|---|---|---|---|---|---|
TD* | Cognitive domain** | Reference | ||||
Gene | Marker | (n) | p-value | (n) | p-value | John et al.40 |
SCN1A | rs10497275 | 91/161 | 0.004 | _ | _ | |
GCLM | rs17881908 | 91/161 | 0.02 | _ | _ | |
MTHFR | rs4846049 | 91/161 | 0.02 | 152/292 | Spatial ability = 0.01 | |
PIP4K2A | rs10734041 | 91/161 | 0.03 | 152/292 | Face memory = 0.009; emotion = 0.03 | |
CLDN5 | rs756654 | 91/161 | 0.04 | 152/292 | _ | |
MAOB | rs2072745 | _ | _ | 152/292 | Spatial ability = 0.02 | |
NRG1 | rs17731664 | _ | _ | 152/292 | Abstraction and mental flexibility = 0.04 | |
COMT | rs165728 | _ | _ | 152/292 | Spatial memory = 0.05; emotion = 0.05 | |
CACNA1b | rs9414688 | _ | _ | 152/292 | Emotion = 0.02; working memory = 0.002; abstraction and mental flexibility = 0.001 | |
SCN1A | rs1813502 | _ | _ | 152/292 | Spatial ability = 0.03 | |
DISC1 | rs16856322 | _ | _ | 152/292 | Sensory motor and emotional processing = 0.03; attention = 0.03 | |
CHGB | rs2821 | _ | _ | 152/292 | Working memory = 0.003 | |
IL1RN | rs9005 | _ | _ | 152/292 | Spatial memory = 0.03; attention = 0.003; abstraction and mental flexibility = 0.05 | |
EGR3 | rs11136094 | _ | _ | 152/292 | Emotion = 0.03; working memory = 0.001 | |
SYN2 | rs17036056 | _ | _ | 152/292 | Emotion = 0.005 | |
GCLM | rs178819088 | 91/161 | 0.02 | _ | _ | |
NRG1 | rs35753505 | _ | _ | 116/170 | Emotion = 0.0331 | Kukshal et al.38 |
NRG2 | rs6994992 | _ | _ | 116/171 | Attention = 0.047 | |
SLC18A2 | rs363285 | _ | _ | TMT b task = 0.025 | ||
