Table 3 Most significant differential expression genes in the weight gain group before and after 3 months of medication

From: Altered gene expression in antipsychotic-induced weight gain

Gene symbol

Base mean before medication

Base mean after medication

Log 2 fold change

Padj

GeneRif annotation

MTRNR2L2

24.81

494.49

4.32

3.27E−135

 

IFI27

127.06

24.68

−2.36

1.56E−51

 

OTOF

193.19

60.32

−1.68

2.34E−45

 

LOC100190986

8.81

89.54

3.35

8.45E−38

 

OLFM4

217.58

605.17

1.48

7.53E−34

 

ADAMTS2

72.83

13.38

−2.44

3.68E−33

 

LTF

2039.45

5013.98

1.30

1.55E−31

 

LCN2

566.25

1383.66

1.29

1.03E−30

BMI

MMP8

297.24

695.90

1.23

6.80E−27

CHOLEST

ABCA13

155.82

399.40

1.36

9.71E−27

 

CEACAM8

321.14

792.53

1.30

3.47E−26

 
  1. Gene symbol: official symbol; base mean before medication: mean normalized counts from condition A; base mean after medication: mean normalized counts from condition B; log 2 fold change: the logarithm, to basis 2, of the fold change; Padj: p value adjusted for multiple testing with the Benjamini–Hochberg procedure, which controls false discovery rate; GeneRif annotation: genes including the strings “BMI” or “cholest” in their GeneRIF definition
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