Table 4 Most significant genes with differential expression in the no weight gain group before and after 3 months of medication

From: Altered gene expression in antipsychotic-induced weight gain

Gene symbol

Base mean before medication

Base mean after medication

Log 2 fold change

Padj

GeneRif annotation

MTRNR2L2

1108.97

41.38

5.37

4.57E−222

 

LOC100190986

112.72

11.74

3.55

3.05E−48

 

IDO1

592.70

2.39

1.26

7.77E−36

BMI

ANKRD22

437.44

2.34

1.23

7.92E−28

 

ADAMTS2

20.24

0.24

−2.06

2.71E−27

 

CXCL10

208.90

2.54

1.34

2.47E−26

 

ART3

223.32

2.47

1.30

5.61E−26

 

DHFR

1808.97

2.57

1.36

4.56E−22

 

GBP5

19955.17

1.90

0.93

2.58E−21

 

SERPING1

1107.86

1.93

0.95

5.52E−21

 
  1. Gene symbol: official symbol; base mean before medication: mean normalized counts from condition A; base mean after medication: mean normalized counts from condition B; log 2 fold change: the logarithm, to basis 2, of the fold change; Padj: p value adjusted for multiple testing with the Benjamini–Hochberg procedure, which controls false discovery rate; GeneRif annotation: genes including the strings “BMI” or “cholest” in their GeneRIF definition
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