Table 6 Differential expression genes included in the four most significant pathways of all four analyses
From: Altered gene expression in antipsychotic-induced weight gain
Analysis | Pathway | Repository | Gene symbols |
|---|---|---|---|
Weight gain vs. no weight gain before medication | Interferon signaling | Reactome | IFI6, FCGR1A, IFIT3, IFIT1, IFITM3, OAS3, IFI27, XAF1, RSAD2, HLA-DRB5, HLA-DRB1, HLA-DQB1 |
Weight gain vs. no weight gain before medication | Interferon α/β signaling | Reactome | IFI6, IFIT3, IFIT1, IFITM3, OAS3, IFI27, XAF1, RSAD2 |
Weight gain vs. no weight gain before medication | Immune system | Reactome | C1QC, IFI6, FCGR1A, IFIT3, IFIT1, IFITM3, OAS3, OLFM4, IFI27, TNFRSF17, XAF1, TNFRSF13B, ITGA2B, ITGB3, CD79A, CD177, SIGLEC11, SIGLEC8, LAIR2, RSAD2, TNFAIP6, SIGLEC1, PI3, LAMA5, PROS1, MUC20, PPBP, DSP, TXNDC5, HLA-DRB5, HLA-DRB1, HLA-DQB1, NEFL, CD274, LCN2 |
Weight gain vs. no weight gain before medication | Cytokine signaling in immune system | Reactome | IFI6, FCGR1A, IFIT3, IFIT1, IFITM3, OAS3, IFI27, TNFRSF17, XAF1, TNFRSF13B, ITGA2B, ITGB3, RSAD2, LAMA5, HLA-DRB5, HLA-DRB1, HLA-DQB1, NEFL, LCN2 |
Weight gain before and after medication | Neutrophil degranulation | Reactome | S100A9, CHIT1, TCN1, MS4A3, MMP8, OLR1, OLFM4, RNASE3, CTSG, MPO, AZU1, PRTN3, ELANE, C19orf59, CEACAM6, CEACAM8, CD177, LILRA3, TNFAIP6, BPI, LTF, CAMP, CRISP3, ABCA13, MGAM, DEFA4, DEFA1, DEFA1B, LCN2 |
Weight gain before and after medication | Innate immune system | Reactome | C1QA, C1QC, C1QB, S100A9, AIM2, CHIT1, C4BPA, MUC2, TCN1, MS4A3, MMP8, OLR1, OLFM4, RNASE3, CTSG, MPO, AZU1, PRTN3, ELANE, C19orf59, CEACAM6, CEACAM8, CD177, LILRA3, TNFAIP6, BPI, LTF, CAMP, C2, CRISP3, ABCA13, MGAM, DEFA4, DEFA1, DEFA1B, DEFA3, LCN2 |
Weight gain before and after medication | Immune system | Reactome | C1QA, C1QC, C1QB, S100A9, AIM2, CHIT1, C4BPA, IFITM3, MUC2, TCN1, MS4A3, MMP8, OLR1, FLT3, OLFM4, RNASE3, CTSG, IFI27, ALOX15, MPO, AZU1, PRTN3, ELANE, C19orf59, CEACAM6, CEACAM8, CD177, PVRL2, SIGLEC8, LILRA3, LILRA5, RSAD2, TNFAIP6, SIGLEC1, BPI, LTF, CAMP, C2, CRISP3, ABCA13, MGAM, DEFA4, DEFA1, DEFA1B, DEFA3, LCN2 |
Weight gain before and after medication | Antimicrobial peptides | Reactome | S100A9, RNASE3, CTSG, PRTN3, ELANE, BPI, LTF, CAMP, DEFA4, DEFA1, DEFA1B, DEFA3, LCN2 |
No weight gain before and after medication | Glucuronidation | WikiPathways | UGT1A8, UGT1A10, UGT1A9, UGT1A7, UGT1A6, UGT1A3, UGT1A1, UGT2B11, UGT2B28 |
No weight gain before and after medication | Ascorbate and aldarate metabolism | KEGG | UGT1A8, UGT1A10, UGT1A9, UGT1A7, UGT1A6, UGT1A3, UGT1A1, UGT2B11, UGT2B28 |
No weight gain before and after medication | Glucuronate pathway (uronate pathway) | KEGG | UGT1A8, UGT1A10, UGT1A9, UGT1A7, UGT1A6, UGT1A3, UGT1A1, UGT2B11, UGT2B28 |
No weight gain before and after medication | Pentose and glucuronate interconversions | KEGG | UGT1A8, UGT1A10, UGT1A9, UGT1A7, UGT1A6, UGT1A3, UGT1A1, UGT2B11, UGT2B28 |
Weight gain vs. no weight gain after medication | Neutrophil degranulation | Reactome | CHIT1, MS4A3, MMP8, OLR1, KRT1, OLFM4, RNASE3, CTSG, HP, MPO, SERPINB10, AZU1, PRTN3, ELANE, CEACAM6, CEACAM8, CD177, PGLYRP1, BPI, SLPI, MMP9, LTF, CAMP, PPBP, DSP, CRISP3, ARG1, ABCA13, CLEC5A, DEFA4, DEFA1, DEFA1B, LCN2 |
Weight gain vs. no weight gain after medication | Immune system | Reactome | C1QB, GBP1, GBP4, GBP5, CD101, SLAMF7, SH2D1B, CHIT1, MS4A3, MMP8, NCAM1, KLRF1, OLR1, KLRD1, KLRC2, KLRC1, KRT1, OLFM4, RNASE3, CTSG, HP, CCL4, ITGA2B, ITGB3, MPO, SERPINB10, AZU1, PRTN3, ELANE, MUC16, CEACAM6, CEACAM8, CD177, PVRL2, PGLYRP1, SIGLEC11, SIGLEC6, LILRA4, KIR2DL3, KIR2DL1, KIR2DL4, KIR3DL1, KIR2DS4, KIR3DL2, NCR1, GNLY, DUSP2, BPI, PI3, SLPI, MMP9, LTF, CAMP, PROS1, PPBP, CXCL10, IL31RA, ERAP2, PDGFRB, DSP, HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQB2, TREML4, CRISP3, ARG1, ABCA13, COL1A2, CLEC5A, DEFA4, DEFA1, DEFA1B, DEFA3, LCN2 |
Weight gain vs. no weight gain after medication | Graft-vs.-host disease | KEGG | PRF1, KLRD1, KLRC1, GZMB, KIR2DL3, KIR2DL1, KIR3DL1, KIR3DL2, HLA-DRB5, HLA-DRB1, HLA-DQB1 |
Weight gain vs. no weight gain after medication | Immunoregulatory interactions between a lymphoid and a non-lymphoid cell | Reactome | SLAMF7, SH2D1B, KLRF1, KLRD1, KLRC1, PVRL2, SIGLEC11, SIGLEC6, LILRA4, KIR2DL3, KIR2DL1, KIR2DL4, KIR3DL1, KIR3DL2, NCR1, TREML4 |
