Fig. 4: Intermediate excitability with intermediate synchrony allowed for high information transfer across tri-scaling manipulations.
From: In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia
Raster plots based on parameters labeled L1, L2 (with reduced information flow), and H1, H2 (with increased information flow) on Fig. 3 for an example simulation. L1 showed low firing; L2 showed high synchrony. H1 and H2 showed similar firing patterns, where both excitability and synchrony were midway in comparison to simulations in L1 and L2. In bottom panel, gamma power reflected the different raster dynamics, with intermediate gamma power for H1 and H2 simulations in comparison to gamma power of simulations L1 and L2. nTE showed an inverted-U pattern with increasing gamma power.
