Fig. 4: Correlation analysis, performed between peripheral endocannabinoid concentrations and the distribution volumes of brain CB1R availability separately between FEP patients HC at the two study sites. | npj Schizophrenia

Fig. 4: Correlation analysis, performed between peripheral endocannabinoid concentrations and the distribution volumes of brain CB1R availability separately between FEP patients HC at the two study sites.

From: Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis

Fig. 4: Correlation analysis, performed between peripheral endocannabinoid concentrations and the distribution volumes of brain CB1R availability separately between FEP patients HC at the two study sites.

a Spearman correlation coefficients between CB1R availability and circulating endocannabinoids in HC from the city of Turku. b Spearman correlation coefficients between CB1R availability and circulating endocannabinoids in FEP from the city of Turku. The correlation coefficient values revealed positive correlation between CB1R availability in different regions of the brain in both FEP and HC. c Spearman correlation coefficients between CB1R availability and circulating endocannabinoids in HC from an inner-city area of London. d Spearman correlation coefficients between CB1R availability and circulating endocannabinoids in FEP from inner-city area of London. There was significant negative association between peripheral arachidonoyl glycerol (1 + 2) concentrations and CB1R availability in certain regions of the brain among HCs, which was absent in FEP patients, at different sites, respectively. Here, the blue gradient represents positive correlation, while the red gradient indicates negative correlation (p-values < 0.05).

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