Fig. 3: Associations between CYP2D6-associated hippocampal white matter connectivity and treatment response after 4 weeks of APD treatment. | npj Schizophrenia

Fig. 3: Associations between CYP2D6-associated hippocampal white matter connectivity and treatment response after 4 weeks of APD treatment.

From: Influence of cytochrome P450 2D6 polymorphism on hippocampal white matter and treatment response in schizophrenia

Fig. 3

Higher FAs (a, b) and lower RDs (c, d) were associated with lesser improvements in positive symptoms (TFCE-corrected p < 0.05). The red (a) and blue areas (b) indicate the regions showing significant differences in FAs and RDs between the IM and EM groups, respectively. CYP2D6 cytochrome P450 2D6, APD antipsychotic drug, FA fractional anisotropy, RD radial diffusivity, PANSS-P the positive symptom subscale of the Positive and Negative Syndrome Scale, TFCE threshold-free cluster enhancement, IM intermediate metabolizer, EM extensive metabolizer.

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