Table 2 Glycosylation enzyme gene and protein expression alterations in schizophrenia brain.

From: Post-translational protein modifications in schizophrenia

Brain region

BA46

BA9/46

BA22

Reference

70

53

52

55

72

54

Glycosylation enzymes

Gene array

Gene RT-PCR short-term DOI

Gene RT-PCR long-term DOI

Gene array

Protein

Protein

Protein

Protein

AGA

  

    

B3GLCT (B3GALTL)

   

  

 

B3GNT2

  

   

B3GNT3

  

   

B3GNT4

  

    

B3GNT8 (B3GNTL1)

   

   

B4GALT1

  

  

 

B4GALT2

   

    

B4GALT3

   

    

B4GALT6

*

     

C1GALT1

  

  

 

C1GALT1C1

  

  

 

EDEM1

   

 

  

EDEM2

   

 

  

EDEM3

   

 

  

FUCA2

   

   

FUT11

  

   

FUT6

*

       

FUT8

  

   

GAL3ST1

     

GALC

     

GALNT10

   

    

GALNT2

  

  

 

GALNT3

   

    

GALNT4

   

    

GALNT5

*

       

GALNT7

  

  

 

GALNT16 (GALNTL1)

  

  

 

GALNTL5

  

  

 

GANAB

   

 

  

GCNT3

   

    

MAN1A1

   

    

MAN1B1

   

 

  

MAN2A2

*

  

    

MGAT1

  

   

MGAT2

   

    

MGAT3

*

  

    

MGAT4A

  

   

MGAT4B

   

   

MGAT4C

   

   

MGAT5

  

   

MGAT5B

   

   

MOGS

   

 

  

NEU1

   

    

NEU2

   

    

NEU3

   

    

OGT

   

    

PDIA3 (ERp57)

     

  

POFUT1

  

   

POFUT2

  

   

ST3GAL1

   

    

ST3GAL2

*

  

    

ST6GAL1

*

  

  

 

ST8SIA3

   

    

ST8SIA6

   

    

UGGT1

   

 

  

UGGT2

   

 

  

UGT8

     
  1. Glycosylation enzymes with reported gene and protein expression differences in schizophrenia brain are summarized from refs. 52,53,54,55,70,72 The direction of gene expression differences in schizophrenia for some enzymes were not specified and are indicated with an asterisk (*). Genes which do not demonstrate differential expression in schizophrenia are listed only if both gene and protein expression of the enzyme have been measured. Symbols: increased expression (↑), decreased expression (↓), no expression difference detected (↔).