Table 2 Region of interest (ROI) validation analysis for the three contrasts using the valence and magnitude cue models.

From: Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity

Contrast

Anatomical labelling

  

Statistics

 

MNI coordinates

   
 

Label

Hemisphere

Z

p(svc)

KE

x

y

 

z

Reward + Punishment > Neutral

         

 Valence model

Thalamus

R

3.84

0.003

20

9

−7

 

−2

 Magnitude model

dAI

L

4.24

0.001

38

−33

23

 

−2

  

R

3.39

0.013

17

42

17

 

−2

 

vAI

L

3.65

0.006

3

−30

20

 

−5

 

NAcc

L

3.33

0.015

5

−3

8

 

−5

  

R

4.60

0.000

25

9

5

 

−5

 

Caudate

R

4.42

0.000

16

9

5

 

−2

  

R

3.28

0.017

3

18

26

 

1

 

Thalamus

L

3.73

0.004

27

−6

−10

 

−2

  

R

3.79

0.003

31

3

−10

 

1

Reward > Punishment

         

 Valence model

 

 Magnitude model

 

High > Low + Neutral

         

 Magnitude model

Caudate

L

4.36

0.000

17

−6

8

 

−2

  

R

4.11

0.001

14

9

5

 

−2

 

NAcc

L

4.26

0.001

29

−6

8

 

−5

  

R

4.38

0.000

12

9

5

 

−5

 

Amygdala

R

4.18

0.001

12

18

−1

 

−17

 

Thalamus

L

3.82

0.003

62

−15

−10

 

10

  

R

3.94

0.002

39

6

−4

 

4

 

dAI

L

3.87

0.002

23

−33

23

 

−5

  

R

4.57

0.000

43

33

23

 

−8

 

vAI

L

3.78

0.003

15

−36

17

 

−5

  

R

4.71

0.000

35

30

20

 

−11

  1. We applied family-wise error (FWE) correction adjusted for small volume [p (svc) < 0.05] within each of the independent ROIs at the voxel level (only ROIs with at least three contiguous voxels were considered significant). There were no significantly different regions for the reward vs punishment contrast.
  2. MNI Montreal Neurological Institute, svc small-volume correction, R right, L left, KE number of voxels in cluster, dAI dorsal anterior insula, vAI ventral anterior insula, NAcc nucleus accumbens.