Table 1 Demographic information of patients with recent-onset psychosis and patients with clinical high-risk for psychosis.
CCu | DCu | Statistical analysis | p | CCu | DCu | Statistical analysis | p | |
|---|---|---|---|---|---|---|---|---|
Discovery sample (ROP; N = 109) | Validation sample (CHR; N = 73) | |||||||
Sample Size [N (%)] | 54 (49.5) | 55 (50.5) | 36 (49.3) | 37 (50.7) | ||||
Sample Size per Study Site [N (%)]: | ||||||||
Munich (%) | 29 (53.7) | 25 (45.5) | χ29 = 11.90 | 0.156 | 12 (33.3) | 15 (40.5) | χ29 = −8.81 | 0.455 |
Milan (%) | 4 (7.4) | 3 (5.5) | 2 (5.6) | 2 (5.4) | ||||
Basel (%) | 9 (16.7) | 3 (5.5) | 4 (11.1) | 1 (2.7) | ||||
Cologne (%) | 2 (3.7) | 9 (16.4) | 6 (16.7) | 10 (27.0) | ||||
Birmingham (%) | 3 (5.6) | 3 (5.5) | 0 (0.0) | 2 (5.4) | ||||
Turku (%) | 4 (7.4) | 7 (12.7) | 3 (8.3) | 2 (5.4) | ||||
Udine (%) | 0 (0.0) | 0 (0.0) | 1 (2.8) | 0 (0.0) | ||||
Bari (%) | 0 (0.0) | 2 (3.6) | 0 (0.0) | 1 (2.8) | ||||
Duesseldorf (%) | 0 (0.0) | 1 (1.8) | 3 (8.3) | 2 (5.4) | ||||
Muenster (%) | 3 (5.6) | 2 (3.6) | 5 (13.9) | 2 (5.4) | ||||
Time of Relapse [mean (SD) days after Baseline] | 97.4 (102.0) | – | 87 (100.1) | – | ||||
Age [mean (SD) years] | 23.8 (4.3) | 25.1 (5.2) | t104 = −1.45 | 0.151 | 22.0 (3.7) | 23.8 (5.2) | t65 = −1.80 | 0.076 |
Sex [Female (%)] | 15 (27.8) | 19 (34.5) | χ21 = 0.31 | 0.578 | 11 (30.6) | 23 (62.2) | χ21 = −6.11 | 0.013 |
Race/ethnicity [N (%)] | ||||||||
White (%) | 43 (79.6) | 42 (76.4) | χ25 = −3.06 | 0.691 | 28 (77.8) | 35 (94.6) | χ23 = −5.64 | 0.131 |
Asian (%) | 4 (7.4) | 5 (9.1) | 2 (5.6) | 0 (0) | ||||
African (%) | 1 (1.9) | 1 (1.8) | 2 (5.6) | 1 (2.7) | ||||
Mixed (%) | 4 (7.4) | 3 (5.5) | 0 (0) | 0 (0) | ||||
Other (%) | 1 (1.9) | 4 (7.3) | 4 (11.1) | 1 (2.7) | ||||
BMI [mean (SD)] | 23.1 (4.1) | 22.9 (4.0) | t97 = −0.30 | 0.763 | 23.5 (4.4) | 22.0 (2.9) | t59 = 1.71 | 0.092 |
Education [mean (SD) years] | 13.3 (2.7) | 13.9 (2.7) | t105 = −1.12 | 0.268 | 13.1 (2.6) | 14.2 (2.7) | t70 = −1.64 | 0.106 |
Educational problems [mean (SD) years repeated] | 0.7 (1.8) | 0.4 (0.7) | t67 = 1.08 | 0.282 | 0.8 (2.2) | 0.9 (2.5) | t68 = −0.21 | 0.837 |
GF-Social: highest lifetime | 7.8 (0.8) | 8.0 (0.8) | t106 = −1.36 | 0.177 | 7.7 (0.9) | 8.1 (0.8) | t68 = −1.64 | 0.107 |
GF-Social: baseline | 5.6 (1.5) | 5.9 (1.5) | t106 = −0.94 | 0.352 | 5.9 (1.4) | 6.6 (1.5) | t71 = −1.93 | 0.058 |
GF-Role: highest lifetime | 7.4 (0.9) | 7.9 (0.9) | t105 = −2.67 | 0.009 | 7.9 (0.9) | 7.9 (0.8) | t69 = −0.16 | 0.877 |
GF-Role: baseline | 4.6 (1.7) | 5.3 (1.9) | t106 = −1.96 | 0.052 | 5.4 (1.9) | 6.0 (1.4) | t64 = −1.60 | 0.114 |
GAF Disability/Impairment Highest Lifetime | 77.5 (8.8) | 78.5 (9.0) | t104 = −0.58 | 0.561 | 76.6 (8.6) | 79.0 (8.3) | t71 = −1.22 | 0.227 |
GAF Disability/Impairment Highest Past Month | 41.3 (10.4) | 49.0 (16.6) | t91 = −2.92 | 0.004 | 48.3 (11.3) | 53.0 (11.2) | t70 = −0.52 | 0.607 |
GAF Symptoms Highest Lifetime | 77.7 (8.5) | 79.6 (9.6) | t106 = −1.07 | 0.286 | 78.0 (9.9) | 79.1 (8.8) | t71 = −1.78 | 0.079 |
GAF Symptoms Highest Past Month | 40 (12.4) | 43.4 (16.4) | t100 = −1.21 | 0.230 | 47.0 (10.2) | 51.8 (11.8) | t70 = −1.86 | 0.067 |
Positive and Negative Syndrome Scale—Positive [mean (SD)] | 20.0 (5.9) | 19.2 (6.0) | t105 = 0.69 | 0.491 | 11.2 (3.5) | 11.5 (3.1) | t67 = −0.36 | 0.718 |
Positive and Negative Syndrome Scale—Negative [mean (SD)] | 15.2 (5.9) | 14.2 (6.5) | t104 = 0.87 | 0.388 | 13.8 (6.8) | 13.9 (6.0) | t67 = −0.07 | 0.941 |
Positive and Negative Syndrome Scale—General [mean (SD)] | 37.0 (10.8) | 31.8 (9.5) | t103 = 2.66 | 0.009 | 30.8 (7.7) | 29.5 (7.6) | t68 = 0.72 | 0.474 |
Becks Depression Inventory [mean (SD)] | 22.9 (14.2) | 19.1 (11.5) | t93 = 1.44 | 0.152 | 27.9 (11.5) | 27.5 (10.4) | t65 = 0.14 | 0.891 |
Lifetime history of DSM-IV Cannabis use disorder [N (%)] | ||||||||
Cannabis abuse (%) | 21 (38.9) | 19 (34.5) | χ22 = −9.61 | 0.008 | 16 (44.4) | 12 (32.4) | χ22 = −1.14 | 0.566 |
Cannabis dependence (%) | 17 (31.5) | 6 (10.9) | 1 (2.8) | 1 (2.7) | ||||
Time since last Cannabis Use at Baseline [mean (SD) months] | 8.7 (25.3) | 33.4 (60.9) | t66 = −2.52 | 0.010 | 10.6 (29.2) | 33.6 (53.8) | t50 = −2.14 | 0.038 |
Duration Lifetime Cannabis Use [mean (SD) months] | 63.7 (50.0) | 51.8 (43.9) | t90 = 1.22 | 0.227 | 52.9 (64.4) | 33.7 (43.4) | t45 = 1.31 | 0.195 |
Age at Cannabis Initiation [mean (SD) years] | 16.5 (2.6) | 17.5 (3.7) | t86 = −1.55 | 0.126 | 17.1 (2.2) | 17.5 (2.7) | t56 = −0.64 | 0.526 |
Average Number of cigarettes smoked per day [mean (SD)] | 8.0 (7.4) | 7.2 (7.6) | t100 = 0.60 | 0.553 | 7.7 (8.6) | 4.6 (6.1) | t63 = 1.71 | 0.093 |
Average Units of alcohol consumed per day [mean (SD)] | 4.4 (4.2) | 5.4 (6.1) | t75 = −0.92 | 0.360 | 4.2 (5.6) | 4.0 (3.3) | t46 = 0.24 | 0.811 |