Table 2 Subcortical volumes at before and 12 weeks after clozapine initiation.

From: Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia

 

Volume baseline (mm3)

Volume 12 weeks (mm3)

PC

SPC (mm3/year)

Statistic

Lateral ventricles

16633; Q1: 10713; Q3: 30120

16838; Q1: 12592; Q3: 31855

7.50 ± 7.27

30.44 ± 29.38*

T23 = 5.07; P < 0.001; d = 1.04

Caudate

7945; Q1: 7000; Q3: 9310

7552; Q1: 6687; Q3: 8990

−3.49 ± 2.40

−15.56 ± 10.83*

T23 = 7.04; P < 0.001; d = 1.44

Putamen

11198 ± 1274

10758 ± 1269

−3.92 ± 2.71

−17.54 ± 12.28*

T23 = 7.00; P < 0.001; d = 1.43

Thalamus

12962 ± 1645

12939 ± 1549

−0.45; −2.14; 1.59

−1.97; −9.30; 6.51

N = 24; z = 0.66; P = 0.51

Hippocampus

7797 ± 694

7735 ± 629

−1.72; −3.21; 0.70

−7.55; −14.06; 2.20

N = 24; z = 1.6; P = 0.11

  1. The table presents data in 24 patients with treatment-resistant schizophrenia who completed MRI at both timepoints. Normally distributed data are expressed as mean ± standard deviation, non-normally distributed data are expressed as median; quartile 1 (Q1); quartile 3 (Q3). PC: Percentage volumetric change, calculated as (volume at follow-up − volume at baseline)/(volume at baseline)*100. The statistical significance of the symmetrized percentage change (SPC) was evaluated using one-sample T-tests for normally distributed data and one sample Wilcoxon signed rank test for non-normally distributed data. * Significant increases in lateral ventricle volume and decreases in caudate and putamen volume were observed over 12 weeks of clozapine treatment.
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