Fig. 2: Effect of the timing of RIS dosing on circadian gene expression in the metabolic tissues. | Schizophrenia

Fig. 2: Effect of the timing of RIS dosing on circadian gene expression in the metabolic tissues.

From: Antipsychotic-induced weight gain and metabolic effects show diurnal dependence and are reversible with time restricted feeding

Fig. 2: Effect of the timing of RIS dosing on circadian gene expression in the metabolic tissues.The alternative text for this image may have been generated using AI.

Circadian Gene Expression in A Hypothalamus, B Liver, C gWAT, of mice treated with risperidone (RIS, 3 mg/kg) or vehicle control (CON) during the light (AM = ZT2) or dark cycle (PM = ZT11) of mice treated with risperidone (RIS, 3 mg/kg) or vehicle control (CON) during the light (AM = ZT2) or dark cycle (PM = ZT11). Inflammatory gene expression in D Hypothalamus, E Liver, F gWAT, of mice treated with risperidone (RIS, 3 mg/kg) or vehicle control (CON) during the light (AM = ZT2) or dark cycle (PM = ZT11) of mice treated with risperidone (RIS, 3 mg/kg) or vehicle control (CON) during the light (AM = ZT2) or dark cycle (PM = ZT11). Data is expressed as mean ± SEM and analyzed using 2-Way ANOVA followed by two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli with a false discovery rate of 0.05. Significance was set at p < 0.05, CON-AM n = 7–8, RIS-AM n = 6–7, CON-PM n = 7–8, RIS-PM n = 7–8). A Hypothalamus (Bmal Drug: F = 0.43, df = 1, p = 0.51, Time: F = 23.72, df = 1, p < 0.001, DrugXTime: F = 0.26, df = 1, p = 0.61, Clock Drug: F = 0.25, df = 1, p = 0.62, Time: F = 0.13, df = 1, p = 0.72, DrugXTime: F = 6.38, df = 1, p = 0.02, Per1 Drug: F = 2.19, df = 1, p = 0.15, Time: F = 8.36, df = 1, p = 0.007, DrugXTime: F = 0.29, df = 1, p = 0.59, Per2 Drug: F = 2.44, df = 1, p = 0.13, Time: F = 16.64, df = 1, p < 0.001, DrugXTime: F = 0.54, df = 1, p = 0.47, Cry1 Drug: F = 1.20, df = 1, p = 0.28, Time: F = 8.19, df = 1, p = 0.008, DrugXTime: F = 1.98, df = 1, p = 0.17, Cry2 Drug: F = 4.97 df = 1, p = 0.03, Time: F = 1.86, df = 1, p = 0.18, DrugXTime: F = 5.71, df = 1, p = 0.02, Rev-erba Drug: F < 0.01, df = 1, p = 0.99, Time: F = 18.63, df = 1, p < 0.001, DrugXTime: F = 2.16, df = 1, p = 0.15), B Liver (Bmal Drug: F = 0.07, df = 1, p = 0.78, Time: F = 0.24, df = 1, p = 0.62, DrugXTime: F < 0.01, df = 1, p = 0.98, Clock Drug: F = 4.1, df = 1, p = 0.05, Time: F = 112.1, df = 1, p < 0.001, DrugXTime: F = 6.38, df = 1, p = 0.02, Per1 Drug: F = 3.66, df = 1, p = 0.067, Time: F = 104.1, df = 1, p < 0.001, DrugXTime: F = 0.94, df = 1, p = 0.34, Per2 Drug: F = 26.32, df = 1, p < 0.001, Time: F = 532.7, df = 1, p < 0.001, DrugXTime: F = 13.38, df = 1, p < 0.001, Cry1 Drug: F = 0.013, df = 1, p = 0.91, Time: F = 61.82, df = 1, p < 0.001, DrugXTime: F = 0.28, df = 1, p = 0.60, Cry2 Drug: F = 3.40 df = 1, p = 0.07, Time: F = 37.47, df = 1, p < 0.001, DrugXTime: F = 0.86, df = 1, p = 0.36, Rev-erba Drug: F = 19.99, df = 1, p < 0.001, Time: F = 371.5, df = 1, p < 0.001, DrugXTime: F = 16.85, df = 1, p < 0.001, Rev-erbb Drug: F = 6.19, df = 1, p = 0.01, Time: F = 7.25, df = 1, p = 0.01, DrugXTime: F = 5.57, df = 1, p = 0.02), C gWAT (Bmal Drug: F = 0.15, df = 1, p = 0.70, Time: F = 28.25, df = 1, p < 0.001, DrugXTime: F = 0.81, df = 1, p = 0.37, Clock Drug: F = 8.60, df = 1, p = 0.008, Time: F = 0.072, df = 1, p = 0.79, DrugXTime: F = 2.47, df = 1, p = 0.13, Per1 Drug: F = 10.73, df = 1, p = 0.003, Time: F = 19.64, df = 1, p < 0.001, DrugXTime: F = 1.05, df = 1, p = 0.31, Per2 Drug: F = 16.15, df = 1, p < 0.001, Time: F = 155.9, df = 1, p < 0.001, DrugXTime: F = 10.35, df = 1, p = 0.03, Cry1 Drug: F = 0.06, df = 1, p = 0.80, Time: F = 23.71, df = 1, p < 0.001, DrugXTime: F < 0.01, df = 1, p = 0.97, Cry2 Drug: F = 8.20, df = 1, p = 0.008, Time: F = 12.11, df = 1, p = 0.002, DrugXTime: F = 0.32, df = 1, p = 0.57, Rev-erba Drug: F = 1.76, df = 1, p = 0.19, Time: 22.22, df = 1, p < 0.001, DrugXTime: F = 1.83, df = 1, p = 0.19, Rev-erbb Drug: F = 0.11, df = 1, p = 0.74, Time: F = 10.58, df = 1, p = 0.003, DrugXTime: F = 0.77, df = 1, p = 39), D Hypothalamus (Il1b Drug: F = 10.72, df = 1, p = 0.003, Time: F = 8.96, df = 1, p = 0.006, DrugXTime: F = 0.37, df = 1, p = 0.55, Il6 Drug: F = 1.31, df = 1, p = 0.26, Time: F = 0.37, df = 1, p = 0.54, DrugXTime: F = 0.32, df = 1, p = 0.57, Tnfa Drug: F = 0.14, df = 1, p = 0.70, Time: F = 1.89, df = 1, p = 0.18, DrugXTime: F = 7.16, df = 1, p = 0.013, Il10 Drug: F = 0.56, df = 1, p = 0.46, Time: F = 0.18, df = 1, p = 0.67, DrugXTime: F = 0.01, df = 1, p = 0.90, Cd11b Drug: F < 0.01, df = 1, p = 0.97, Time: F = 1.14, df = 1, p = 0.29, DrugXTime: F = 2.07, df = 1, p = 0.16, Cd11c Drug: F = 0.002, df = 1, p = 0.88, Time: F = 5.79, df = 1, p = 0.02, DrugXTime: F = 3.05, df = 1, p = 0.09), E Liver (Il1b Drug: F = 36.47, df = 1, p < 0.001, Time: F = 11.21, df = 1, p = 0.002, DrugXTime: F = 9.64, df = 1, p = 0.004, Il6 Drug: F = 0.18, df = 1, p = 0.67, Time: F = 0.19, df = 1, p = 0.66, DrugXTime: F = 1.20, df = 1, p = 0.28, Tnfa Drug: F = 0.05, df = 1, p = 0.81, Time: F = 16.2, df = 1, p < 0.001, DrugXTime: F = 0.56, df = 1, p = 0.45, Il10 Drug: F = 5.97, df = 1, p = 0.02, Time: F = 1.88, df = 1, p = 0.18, DrugXTime: F = 3.41, df = 1, p = 0.08, Cd11b Drug: F = 10.52, df = 1, p = 0.003, Time: F < 0.01, df = 1, p = 0.97, DrugXTime: F = 0.07, df = 1, p = 0.80, Cd11c Drug: F = 3.79, df = 1, p = 0.06, Time: F = 8.39, df = 1, p = 0.007, DrugXTime: F = 1.64, df = 1, p = 0.21), F gWAT (Il1b Drug: F = 1.67, df = 1, p = 0.20, Time: F = 1.76, df = 1, p = 0.19, DrugXTime: F = 6.15, df = 1, p = 0.02, Il6 Drug: F = 0.11, df = 1, p = 0.73, Time: F = 4.25, df = 1, p = 0.05, DrugXTime: F = 0.03, df = 1, p = 0.85, Tnfa Drug: F = 2.57, df = 1, p = 0.12, Time: F = 5.65, df = 1, p = 0.02, DrugXTime: F = 1.29, df = 1, p = 0.27, Il10 Drug: F = 0.11, df = 1, p = 0.74, Time: F = 11.05, df = 1, p = 0.003, DrugXTime: F = 13.39, df = 1, p = 0.001, Cd11b Drug: F = 2.15, df = 1, p = 0.15, Time: F = 0.07, df = 1, p = 0.80, DrugXTime: F = 1.67, df = 1, p = 0.21, Cd11c Drug: F = 0.20, df = 1, p = 0.65, Time: F = 1.57, df = 1, p = 0.22, DrugXTime: F = 4.0, df = 1, p = 0.06).

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