Fig. 1: Experimental layout and data flow. | Schizophrenia

Fig. 1: Experimental layout and data flow.

From: Spironolactone alleviates schizophrenia-related reversal learning in Tcf4 transgenic mice subjected to social defeat

Fig. 1

A Experimental timeline. Tcf4tg-mice were all subjected to social stress during early adolescence (Tcf4tgSD). The behavioral tests were performed according to the previously published PsyCoP protocol with tail suspension test and pre-pulse inhibition test reversed and in order of increasing aversiveness17. B Overview of the data analysis pipeline. Data acquisition and preprocessing were semi-automated. All data were collected in a RData dump for further analysis in FlowR. The variables were categorized in domains following the Research Domain Criteria (RDoC) framework. Canonical discriminant analysis (CDA) was used for dimension reduction. The resulting neurocognitive profiles were visualized in dimension plots of the dimension reduction and a heatmap of the weights of each variable in the CDA result.

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