Table 1 Results of linear mixed-effects models fit with treatment, time, and baseline neuropsychological performance on THC content in urine.

From: Neurocognitive moderation of repetitive transcranial magnetic stimulation (rTMS) effects on cannabis use in schizophrenia: a preliminary analysis

Neuropsychological measure	Fixed effects	Estimate	SE	df	t	p
NarcoCheck (ng/mL)
HVLT-R composite	Intercept	343.89	50.13	18.13	6.86	<0.001***
	Treatment	−14.72	50.13	18.13	−0.29	0.77
	Time	54.03	21.03	16.70	2.57	0.020*
	HVLT-R	−33.40	51.60	35.82	−0.65	0.52
	Treatment x Time	31.40	21.03	16.70	1.49	0.15
	Treatment x HVLT-R	−88.43	51.60	35.82	−1.71	0.095
	Time x HVLT-R	−24.01	30.56	18.24	−0.79	0.44
	Treatment x Time x HVLT-R	−28.54	30.56	18.24	−0.93	0.36
SDR composite	Intercept	348.11	48.98	18.80	7.11	<0.001***
	Treatment	−28.83	48.98	18.80	0.59	0.56
	Time	51.51	22.61	17.82	2.28	0.035*
	SDR	12.81	55.77	30.18	0.23	0.82
	Treatment x Time	38.52	22.61	17.82	1.70	0.11
	Treatment x SDR	−18.63	55.77	30.18	−0.33	0.74
	Time x SDR	41.02	39.40	18.21	1.04	0.31
	Treatment x Time x SDR	63.47	39.40	18.21	1.61	0.12
CPT attentional index	Intercept	375.15	40.05	14.94	9.37	<0.001***
	Treatment	2.39	40.05	14.94	0.06	0.95
	Time	49.15	23.42	13.18	2.10	0.055
	CPT	42.21	21.93	23.50	1.92	0.066
	Treatment x Time	34.11	23.42	13.18	1.46	0.16
	Treatment x CPT	−69.87	21.93	23.50	−3.19	<0.01**
	Time x CPT	−5.98	15.12	16.02	−0.40	0.69
	Treatment x Time x CPT	−5.21	15.12	16.02	−0.34	0.73
CPT hit rate	Intercept	604.68	363.62	32.85	1.66	0.11
	Treatment	106.31	363.62	32.85	0.29	0.77
	Time	64.71	193.93	18.04	0.33	0.74
	CPT	−0.59	0.90	32.71	−0.65	0.52
	Treatment x Time	94.30	193.93	18.04	0.49	0.63
	Treatment x CPT	−0.25	0.91	32.71	−0.27	0.79
	Time x CPT	−0.04	0.49	18.73	−0.09	0.93
	Treatment x Time x CPT	−0.18	0.49	18.73	−0.37	0.72
DS forward	Intercept	892.16	126.93	31.05	7.03	< 0.001***
	Treatment	45.56	126.93	31.05	0.36	0.72
	Time	−10.40	61.20	14.70	−0.17	0.87
	DS	−52.31	10.90	22.76	−4.80	<0.001***
	Treatment x Time	196.69	61.20	14.70	3.21	0.005**
	Treatment x DS	−5.04	10.90	22.76	−0.46	0.65
	Time x DS	4.67	5.76	14.61	0.81	0.43
	Treatment x Time x DS	−17.07	5.76	14.61	−2.96	0.01**
TOL total correct	Intercept	663.55	347.73	11.71	1.91	0.08
	Treatment	−185.48	347.73	11.71	−0.53	0.60
	Time	450.77	218.34	8.63	2.07	0.07
	TOL	−5.0	3.62	10.96	−1.38	0.20
	Treatment x Time	−601.89	218.34	8.63	−2.76	0.023*
	Treatment x TOL	2.85	3.62	10.96	0.79	0.45
	Time x TOL	−4.98	2.34	8.85	−2.13	0.062
	Treatment x Time x TOL	6.49	2.34	8.85	2.77	0.022*
KDDT Geometrick K	Intercept	256.04	101.30	25.94	2.53	0.02*
	Treatment	−297.53	101.30	25.94	−2.94	0.007**
	Time	−13.33	72.86	13.85	−0.18	0.85
	Geo K	−15.64	21.23	14.54	−0.74	0.47
	Treatment x Time	−134.64	72.85	13.85	−1.85	0.08
	Treatment x Geo K	−80.39	21.23	14.54	−3.79	0.001**
	Time x Geo K	−9.54	18.29	13.83	−0.52	0.61
	Treatment x Time x Geo K	−42.20	18.29	13.83	−2.31	0.037*

Hopkins Verbal Learning Test (HVLT-R), the Spatial Delayed Response (SDR), Continuous Performance Test (CPT), Digit Span (DS), Tower of London (TOL), Kirby Delay-Discounting Task (KDDT).
Bold values in the table represent significant interactions of interest (p < 0.05)
*p < 0.05; **p < 0.01; ***p < 0.001

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Table 1 Results of linear mixed-effects models fit with treatment, time, and baseline neuropsychological performance on THC content in urine.

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