Table 1 Fixed effects calculated with SPSS for expression and methylation correlation estimates in cingulum cortex.
Estimates of fixed effects | ||||||||
|---|---|---|---|---|---|---|---|---|
Area | Substance | Puberty | Estimate | Std. error | Sig. | 95% confidence interval | ||
Lower bound | Upper bound | |||||||
Cingulum cortex (Drd2) | Sham | Pre-adolescent | Methylation | 0.222 | 0.061 | 0.000 | 0.101 | 0.343 |
Post-adolescent | Methylation | 0.029 | 0.106 | 0.783 | −0.180 | 0.239 | ||
MAM | Pre-adolescent | Methylation | −0.684 | 0.115 | 0.000 | −0.912 | −0.456 | |
Post-adolescent | Methylation | 0.017 | 0.128 | 0.890 | −0.235 | 0.271 | ||
Cingulum cortex (Disc1) | Sham | Pre-adolescent | Methylation | 0.098 | 0.034 | 0.005 | 0.0295 | 0.166 |
Post-adolescent | Methylation | −0.339 | 0.254 | 0.183 | −0.841 | 0.161 | ||
MAM | Pre-adolescent | Methylation | −0.030 | 0.060 | 0.614 | −0.149 | 0.088 | |
Post-adolescent | Methylation | −0.027 | 0.045 | 0.554 | −0.117 | 0.063 | ||
Cingulum cortex (Syp) | Sham | Pre-adolescent | Methylation | −0.150 | 0.021 | 0.000 | −0.192 | −0.108 |
Post-adolescent | Methylation | 0.383 | 0.084 | 0.000 | 0.217 | 0.550 | ||
MAM | Pre-adolescent | Methylation | −0.222 | 0.076 | 0.004 | −0.372 | −0.073 | |
Post-adolescent | Methylation | 0.157 | 0.046 | 0.001 | 0.066 | 0.247 | ||
Cingulum cortex (Dtnbp1) | Sham | Pre-adolescent | Methylation | −0.226 | 0.026 | 0.000 | −0.277 | −0.174 |
Post-adolescent | Methylation | 0.256 | 0.066 | 0.000 | 0.124 | 0.387 | ||
MAM | Pre-adolescent | Methylation | −0.359 | 0.121 | 0.003 | −0.598 | −0.120 | |
Post-adolescent | Methylation | 0.049 | 0.030 | 0.103 | −0.010 | 0.108 | ||
