Fig. 2: Effects of chronic exposure to therapeutic relevant concentration of clozapine and brexpiprazole (0.3 μM) on levels of IP3, cAMP, AMP and ATP in the cultured astrocytes and the hypothalamus. | Schizophrenia

Fig. 2: Effects of chronic exposure to therapeutic relevant concentration of clozapine and brexpiprazole (0.3 μM) on levels of IP3, cAMP, AMP and ATP in the cultured astrocytes and the hypothalamus.

From: Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain

Fig. 2

Effects of chronic exposure (for 14-d) to therapeutic relevant concentration of clozapine (3 μM) and brexpiprazole (0.3 μM) on levels of IP3 (A), cAMP (B), AMP (C) and ATP (D) in the cultured astrocytes. Effects of chronic administration (for 14-d) of effective dose of clozapine (5 mg/kg/day) and brexpiprazole (10 mg/kg/day) on levels of IP3 (E), cAMP (F), AMP (G) and ATP (H) in the hypothalamus. Ordinate: mean ± SD (n = 6) of intracellular levels of IP3 and cAMP (fmol/mg protein), or AMP and ATP (pmol/mg). *p < 0.05, **p < 0.01: relative to control (agent free) by student T-test.

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