Fig. 1: Differentially expressed genes and pathways in HI-SCZ versus LI-SCZ. | Schizophrenia

Fig. 1: Differentially expressed genes and pathways in HI-SCZ versus LI-SCZ.

From: RNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation

Fig. 1

A Volcano plot showing 718 significantly differentially expressed genes in the HI-SCZ compared to LI-SCZ groups based on RNA sequencing data analysis (grey dots). A positive log2 fold change represents increased gene expression in HI-SCZ relative to LI-SCZ (ranging from 25% to 561% increase in expression). Genes of interest in the SEZ, including various cell type markers, are labelled in blue (down-regulation) and red (up-regulation). Note that the second annotated SERPINA3 gene (ENSG00000273259) is reported to undergo nonsense-mediated mRNA decay (NMD), whereas ENSG00000196136 is the primary gene annotation. B Top ten most significant canonical pathways identified by IPA based on all differentially expressed genes in HI-SCZ compared to LI-SCZ. Orange colouring indicates overall pathway activation based on positive IPA canonical pathway z-scores, grey colouring (in B) represents pathways ineligible for z-score prediction (based on inadequate information in the IPA knowledge base); however, the majority (85%) of genes in the top pathway are increased in HI-SCZ. FDR false-discovery rate adjusted, GP6 Glycoprotein VI, IGF1 insulin-like growth factor 1, VDR/RXR vitamin D receptor/retinoid X receptor.

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