Fig. 3: Increased expression of genes contributing to extracellular matrix and angiogenesis in the top differentially expressed pathway ‘Hepatic Fibrosis / Hepatic Stellate Cell Activation’. | Schizophrenia

Fig. 3: Increased expression of genes contributing to extracellular matrix and angiogenesis in the top differentially expressed pathway ‘Hepatic Fibrosis / Hepatic Stellate Cell Activation’.

From: RNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation

Fig. 3

A Ten collagen genes had significantly increased expression in HI-SCZ compared to LI-SCZ, along with four other genes (CCN2, FN1, TIMP1and TGFB2) for which increased expression is typical in fibrosis and extracellular matrix stiffening. B VEGFA and its receptors FLT1 and FLT4, which initiate angiogenesis, were significantly increased in HI-SCZ compared to LI-SCZ, along with markers for endothelial (END1, ECE1) and smooth muscle cells (MYH11, MYL9, ACTA2). Data is represented as the mean with standard error of the mean; *q < 0.05; **q < 0.01; ***q < 0.001; ****q < 0.00001.

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