Table 1 Cohort demographic details and statistical comparisons between inflammatory subgroups.

From: RNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation

 

LI-SCZ n = 13

HI-SCZ n = 14

Statistics

Age at death in years

43.23 ± 11.10 (19-61)

50.21 ± 9.55 (35-68)

t(25)= -1.76, p = 0.09

pH

6.56 ± 0.26 (6.10-6.91)

6.49 ± 0.22 (6.18-6.93)

t(25) = 0.75, p = 0.46

PMI in hours

26.38 ± 11.08 (9-42)

28.82 ± 8.78 (16-47)

t(25) = -0.64, p = 0.53

RIN

8.04 ± 0.64 (7.10-9.10)

7.94 ± 0.33 (7.50-8.50)

t(17.75) = 0.52, p = 0.61

Sex

8 M/5 F

7 M/7 F

χ2 (1, N = 27) = 0.36, p = 0.55

Brain hemisphere

5 Left, 8 Right

6 Left, 8 Right

χ2 (1, N = 27) = 0.05, p = 0.82

Age of onset in years

23.69 ± 7.32

19.43 ± 4.33

t(19.18) = 1.83, p = 0.08

Duration of illness in years

19.54 ± 13.24

30.79 ± 8.45

t(25) = -2.65, p = 0.01

Lifetime antipsychotic dosea (mg)

59,055 ± 108,506

143,458 ± 146,903

t(25) = -1.69, p = 0.10

Antidepressant use

3

3

χ2 (1, N = 27) = 0.01, p = 0.92

Smoking at time of death

7 Yes, 2 No, 4 Unknown

13 Yes, 0 No, 1 Unknown

 

Suicide

4

0

 

Cause of death

Cardiac: 7, OD: 1, Pneumonia: 1, Asphyxiation: 2, Trauma: 2

Cardiac: 6, OD:1, Pneumonia: 3, Cirrhosis:1, Pulmonary: 1, Asthma: 1, Pancreatitis:1

 
  1. Data are shown as mean ± 1 standard deviation. Ranges are presented in parentheses. afluphenazine equivalents in mg; F female, HI-SCZ high inflammation schizophrenia subgroup. LI-SCZ low inflammation schizophrenia subgroup, M male, OD over dose, PMI post-mortem interval, RIN RNA integrity number.