Fig. 5: Correlation and mediation analysis.

Correlation of mean CTC connectivity with GABA (a) and PANSS total score with Glx (b) and Glx/GABA (c), mediation analysis of cerebellar GABA on CTC hyperconnectivity in SCZ (d). Abbreviations: CTC, cerebello-thalamo-cortical; Glx, Glutamate + Glutamine; GABA, gamma-aminobutyric acid; PANSS, positive and negative syndrome scale; ACME, average causal mediation effect; ADE, average direct effect.