Table 1 Demographic, clinical and neurocognitive variables.

From: Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity

Variables

CHR

HC

t/χ2

p

Biotype 1

Biotype 2

Biotype 3

F/χ2

p

Cases (N)

151

88

–

–

45

29

77

–

–

Demographic variables

 Age (year)

19.05 (5.45)

18.63 (4.71)

0.605

0.546

18.42 (0.81)

18.96 (1.03)

19.33 (0.62)

0.391

0.677

 Gender (F/M)

79/72

40/48

1.048

0.306

27/18

16/13

36/41

2.115

0.347

 Education (year)

11.04 (2.67)

11.61 (2.38)

−0.609

0.543

11.24 (0.4)

11.11 (0.51)

11.64 (0.31)

0.538

0.585

SIPS

 Positive

9.87 (3.61)

0.44 (0.84)

168.395

<0.001

9.71 (0.53)

9.54 (0.68)

9.99 (0.41)

0.193

0.824

 Negative

11.76 (5.9)

0.3 (0.76)

169.167

<0.001

10.78 (0.87)

10.32 (1.1)

12.73 (0.66)

2.566

0.091

 Disorganization

6.22 (2.98)

0.3 (0.48)

165.118

<0.001

6.13 (0.44)

5.5 (0.56)

6.46 (0.34)

1.083

0.341

 General

8.91 (2.87)

0.61 (0.96)

164.452

<0.001

8.87 (0.42)

8.43 (0.53)

9.03 (0.32)

0.459

0.633

 Before GAF

78.34 (7.36)

80.74 (1.91)

−2.990

0.003

77.16 (1.1)

78.86 (1.4)

78.83 (0.84)

0.816

0.444

 Now GAF

56.82 (7.77)

80.3 (2.2)

−27.675

<0.001

56.22 (1.16)

58.21 (1.47)

56.75 (0.89)

0.580

0.561

MCCB

 TMT

33.93 (16.3)

28.18 (8.63)

3.064

0.002

32.31 (2.32)

32.5 (2.94)

34.57 (1.78)

0.313

0.732

 BACS_SC

56.75 (10.48)

66.22 (9.49)

−6.971

<0.001

58.18 (1.57)

57.14 (1.99)

55.87 (1.2)

0.688

0.504

 HVLT-R

22.99 (4.75)

26.34 (3.61)

−5.719

<0.001

23.82 (0.7)

23.25 (0.89)

22.53 (0.54)

1.052

0.352

 WMS-III_SS

15.97 (3.23)

17.43 (3.01)

−3.452

0.001

16.58 (0.47)

14.75 (0.59)

16.16 (0.36)

3.864

0.023

 NAB_Mazes

16.77 (6.55)

19.5 (4.9)

−3.397

0.001

18.09 (0.97)

16.43 (1.23)

16.23 (0.74)

1.169

0.313

 BVMT-R

26.37 (6.54)

29.91 (4.71)

−4.447

<0.001

27.96 (0.97)

26.29 (1.23)

25.56 (0.74)

1.686

0.189

 Fluency

19.4 (4.88)

23.14 (5.02)

−5.650

<0.001

19.73 (0.73)

19.18 (0.93)

19.33 (0.56)

0.179

0.837

 CPT_IP

2.4 (0.76)

2.58 (0.7)

−1.701

0.090

2.5 (0.11)

2.27 (0.14)

2.4 (0.09)

0.788

0.457

  1. CHR Clinical high-risk for psychosis, HC Healthy control, F Female, M Male, GAF Global Assessment of Functioning, SIPS Structured Interview for Prodromal Symptoms, MCCB the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery, TMT Trail Making Test: Part A, BACS_SC Brief Assessment of Cognition in Schizophrenia: Symbol Coding, HVLT-R Hopkins Verbal Learning Test-Revised, WMS-III_SS Wechsler Memory Scale-Third Edition: Spatial Span, NAB Neuropsychological Assessment Battery: Mazes, BVMT-R Brief Visuospatial Memory Test-Revised, Fluency Category Fluency Test: Animal naming, CPT-IP Continuous Performance Test, Identical Pairs version. The bold values in the p-value column indicate statistically significant differences.
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