Fig. 1: Visualization of main and interacting associations of PRScs-auto-SCZ75 and ES-SCZ75 at the 2-year follow-up on distressing PEs with varying degrees of symptom persistence at the 3-year follow-up. | Schizophrenia

Fig. 1: Visualization of main and interacting associations of PRScs-auto-SCZ75 and ES-SCZ75 at the 2-year follow-up on distressing PEs with varying degrees of symptom persistence at the 3-year follow-up.

From: Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry

Fig. 1: Visualization of main and interacting associations of PRScs-auto-SCZ75 and ES-SCZ75 at the 2-year follow-up on distressing PEs with varying degrees of symptom persistence at the 3-year follow-up.

Model 1: adjusted for age and sex; Model 2: adjusted for age, sex, family income, and parental education; Upper panel: Main effects of PRScs-auto-SCZ75 (additionally adjusted for 10 PCs); Middle panel: Main effects of ES-SCZ75 (additionally adjusted for distressing PEs up to the 2-year follow-up for past-month distressing PEs); Lower panel: Additive interaction between PRScs-auto-SCZ75 and ES-SCZ75 (additionally adjusted for 10 PCs for all outcomes and distressing PEs up to the 2-year follow-up for past-month distressing PEs). OR, odds ratio; RERI, relative excess risk due to interaction.

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