Fig. 8: Changes in behaviors and the metabolic levels of DA and FA in the MK801-model mice.
From: External stress, formaldehyde, and schizophrenia: a new mouse model for mental illness research
A Microinfusion of MK801 into the VTA in mice. VTA ventral tegmental area. B, C Anxiety-like behaviors assessed by the marble burying test (MBT) and open-field test (OFT), respectively. D Depression-lie behaviors evaluated by the tail suspension test (TST) and sucrose preference test (SPT), respectively. E Short-term memory assessed by Y-maze test. F, G FA levels in the PFC and VTA detected by NaFA probe. FA formaldehyde. H, I TH activity in the PFC and VTA detected by ELISA kits. TH tyrosine dehydrogenase, PFC prefrontal cortex, VTA ventral tegmental area, ELISA enzyme-linked immunosorbent assay. J, K MAO activity in the PFC and VTA detected by ELISA kits. MAO monoamine oxygenase. L, M DA levels in the PFC and VTA quantified by ELISA kits. DA dopamine. N Location and injection of MK801. O Anxiety associated with low activity of GABA neurons in the VTA. P Cognitive decline by FA-blocked NMDAR and depression accompanied by low levels of DA in the PFC. *p < 0.05; **p < 0.01; NS no statistical significance.
