Table 2 Linear mixed models of metabolic components and CGI-S score by groups in the matched population.

From: Associations between second-generation antipsychotics and metabolic outcomes in patients with schizophrenia and metabolic abnormalities

 

OR (95% CI) / RR (95% CI) / β (95% CI)

4 weeks

8 weeks

3 months

6 months

Metabolic syndromea

0.95 (0.68, 1.31)

0.54 (0.37, 0.78)

0.66 (0.43, 1.00)

0.47 (0.30, 0.72)

Number of metabolic abnormalitiesb

0.97 (0.90, 1.04)

0.86 (0.80, 0.93)

0.85 (0.77, 0.93)

0.79 (0.71, 0.87)

Metabolic parametersc

 Weight, kg

−0.613 (−1.521, 0.295)

−1.525 (−2.433, −0.617)

−1.937 (−2.845, −1.028)

−3.153 (−4.061, −2.245)

 Waist circumference, cm

0.570 (−1.445, 2.586)

−0.164 (−2.179, 1.852)

0.135 (−1.881, 2.151)

−1.086 (−3.101, 0.930)

 Systolic blood pressure, mmHg

−0.946 (−3.198, 1.306)

−1.224 (−3.476, 1.028)

−1.341 (−3.593, 0.911)

−0.673 (−2.925, 1.579)

 Diastolic blood pressure, mmHg

1.229 (−0.445, 2.902)

0.744 (−0.929, 2.418)

0.233 (−1.441, 1.907)

−0.018 (−1.692, 1.656)

 Glucose, mmol/L

−0.008 (−0.183, 0.166)

−0.033 (−0.208, 0.141)

−0.084 (−0.258, 0.091)

−0.208 (−0.382, −0.033)

 Triglyceride, mmol/L

−0.083 (−0.227, 0.062)

−0.215 (−0.360, −0.071)

−0.313 (−0.458, −0.169)

−0.374 (−0.518, −0.230)

 HDL-C, mmol/L

0.042 (−0.037, 0.122)

0.045 (−0.035, 0.124)

0.067 (−0.012, 0.147)

0.048 (−0.031, 0.128)

CGI-S scoreb

−0.314 (−0.490, −0.138)

−0.329 (−0.511, −0.146)

−0.234 (−0.445, −0.024)

−0.155 (−0.387, 0.077)

  1. OR odds ratio, RR risk ratio, CI confidence interval, HDL-C high density lipoprotein cholesterol, CGI-S Clinical Global Impressions scale-Severity.
  2. Adjusted for dose of SGAs.
  3. aOR (95% CI) for generalized estimated equations with log-binomial link.
  4. bRR (95% CI) for generalized estimated equations with log-Poisson link.
  5. cβ (95% CI) for linear mixed models.
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